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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/9045

Title :[原著]HPV E6 is an H_2O_2 responsive molecule associated with IL-8 production
Authors :Takemoto, Hiroyuki
Kina, Shinichiro
Arakaki, Keiichi
Matayoshi, Akira
Liang, Feixin
Phonaphonh, Thongsavanh
Kuang, Hai
Sunakawa, Hajime
Authors alternative :嵩元, 裕之
喜名, 振一郎
新垣, 敬一
又吉, 亮
砂川, 元
Authors affiliation :Department of Clinical Neuroscience Oral and Maxillofacial Functional Rehabilitation, University of the Ryukyus
Department of Oral and Maxillofacial Surgery, Guangxi Medical University
Issue Date :2010
Publisher :琉球医学会
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :1346-888X
Abstract :Angiogenesis induced by inflammation occurs in infected sites and is crucial for the initiation of cancer progression. In cervical cancer, IL-8 (Interleukin-8) production is linked to cancer progression. At inflamed sites, neutrophils deploy a potent antimicrobial arsenal, including ROS. Here, we show that a ROS (H_2O_2) activates p38 MAPK to increase the expression of IL-8 in HeLa cells (HPV18-positive cells). We found that knockdown of HPV (Human Papillomavirus) E6 inhibited H_2O_2- and MG132-induced IL-8 production in HeLa cells. These findings elucidate an interesting signaling pathway by which inflammation can induce angiogenesis to cause cervical cancer progression.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/9045
Citation :琉球医学会誌 = Ryukyu Medical Journal Vol.29 no.3・4 p.23 -30
Appears in Collections:Ryukyu Medical Journal

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