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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/4161

 
Title :[原著]Establishment of a Cell Line Derived from Human Osteosarcoma
Authors :Matsui, Katsuaki
Yumoto, Tokichi
Nashiro, Junko
Hashimoto, Kimio
Furuse, Kiyoo
Morimoto, Kanehito
Akeho, Masahiro
Maeyama, Iwao
Authors affiliation :1st Department of Pathology, University of the Ryukyus, School of Medicine
1st Department of Pathology, Tottori University School of Medicine
Department of Orthopedics, Tottori University School of Medicine
Issue Date :1982
Publisher :琉球大学医学部
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :0285-9270
Abstract :Establishment of the cell line ( HOS-O ) of osteosarcoma was successfully accomplished. The materials for this study were obtained from surgically removed tumor mass metastasized to the lung The patient was a 10 year-old girl, suffering from an original tumor in the right distal femur. The tissue culture has been started in September 1977, and the cell line has been maintained in a good condition for about five years. The shape of cultured cells is elongated-spindle and its chromosome number is 46. By histochemical examination, the cells revealed weakly positive at alkaline phosphatase, and moderately positive at acid phosphatase, and highly positive at nonspecific esterase and 5'-nucleotidase. Each of twice transplantations of those cells, to the back of nude mice, was successful. Histological features of the trasplanted tumors were resembled to that of the original sarcoma, showing a remarkable formation of osteoid tissue.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/4161
Citation :琉球大学保健学医学雑誌=Ryukyu University Journal of Health Sciences and Medicine Vol.5 no.3 p.187 -195
Appears in Collections:Ryukyu University Journal of Health Sciences and Medicine

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