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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/3232

 
Title :[原著]C型慢性肝炎に対する$ \beta $-インターフェロンの使用経験
Title alternative :Treatment of chronic hepatitis C with beta interferon
Authors :佐久川 廣
金城, 福則
斎藤, 厚
城間, 盛光
平良, 健康
長堂, 朝圭
仲宗根, 和則
石川, 清和
真喜志, 金造
湧田, 森明
Authors alternative :Sakugawa, Hiroshi
Kinjo, Fukunori
Saito, Atsushi
Shiroma, Seiko
Taira, Kenko
Nagado, Chokei
Nakasone, Kazunori
Ishikawa, Kiyokazu
Makishi, Kinzo
Wakuta, Moriaki
Authors affiliation :琉球大学医学部第一内科
沖縄県立南部病院内科
沖縄協同病院内科
琉生病院内科
沖縄県立北部病院内科
国立療養所沖縄病院内科
博愛病院内科
Issue Date :1995
Publisher :琉球医学会
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :1346888X
0289-1530
Abstract :Thirteen patients with histologically proven chronic hepatitis type C were treated with natural beta interferon (IFN). Most of the patients were administered intravenously, 6 million units (MU) of the IFN daily forabout 6 to 8 weeks, with a total dose of 192-375 MU. Of the 13 patients, 3 (23.1%) achieved a complete response, defined as a normalization of alanine aminotransferase (ALT) levels for longer than six months after treatment was discontinued, and one patient (7.7%) showed a partial response, defined as a decrease of ALT to levels within twice the normal range for longer than six months after withdrawal. In the remaining 9 patients, 4 had a significant decrease of serum ALT during the therapy, but relapsed after the therapy. The remaining 5 patients showed no significant change in ALT during and after the IFN treatment. Side effects (flu-like syndrome, anorexia, proteinurea, etc.) were observed in 11 patients during the IFN therapy but not seen after the therapy. The treatment was well tolerated in all but one patients who suffered from granulocytopenia during the therapy resulting in dropout.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/3232
Citation :琉球医学会誌 = Ryukyu Medical Journal Vol.15 no.4 p.199 -202
Appears in Collections:Ryukyu Medical Journal

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