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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/24888

Title :Usefulness of separately evaluating lymphatic and venous vessel invasion in cervical adenocarcinoma
Authors :Taira, Yusuke
Shimoji, Yuko
Nakasone, Tadaharu
Arakaki, Yoshihisa
Nakamoto, Tomoko
Ooyama, Takuma
Kudaka, Wataru
Kaneshima, Itomi
Nishihira, Kumiko
Aoki, Yoichi
Authors affiliation :Department of Obstetrics and Gynecology, Graduate School of Medicine
Issue Date :2020
Publisher :琉球医学会
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :1346-888X
Abstract :Uterine cervical adenocarcinoma is less sensitive to radiation and chemotherapy than squamous cell carcinoma, and thus, its management includes surgical treatment. We evaluated lymphatic and venous vessel invasion separately in surgical specimens to predict prognosis and recurrence. We retrospectively analysed data from the medical records of 108 patients who were diagnosed with cervical adenocarcinoma or adenosquamous carcinoma and underwent abdominal radical hysterectomy in our institution from January 1993 to April 2017. Lymphatic and venous vessel invasion was separately evaluated in all patient samples using immunohistochemical staining with D2-40 and haematoxylin and eosin (H&E)-Victoria blue double staining, respectively. Clinicopathological and prognostic findings were classified by ly and v status, 66 (61.1%) were both ly (-) and v (-), invasion in ly and/or v were observed in 42 patients (38.9%); specifically, 7 ly (-) / v (+) (6.5%), 24 ly (+) / v (-) (22.2%), and 11 ly (+) / v (+) patients (10.2%), suggesting that deep stromal invasion and pelvic lymph node metastasis was significantly higher in the ly(+) and v (+) groups. Multiple logistic regression analysis of risk factor for local and distant recurrences identified FIGO stage IB2 or higher (odds ratio (OR); 6.437, p=0.0143) and v (OR; 9.290, p=0.0036) as independent risk factors for distant recurrence. In conclusion, we propose that by separately evaluating lymphatic and blood vessel invasions, useful information on prognosis about distant recurrence in cervical adenocarcinoma can be obtained.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/24888
Citation :琉球医学会誌 = Ryukyu Medical Journal Vol.39 no.1-4 p.21 -28
Appears in Collections:Ryukyu Medical Journal

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