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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/24768

 
Title :High Risk Human Papillomavirus Genotype Distribution and its Relevance to Cytology in Lao PDR
Authors :Nakachi, Saori
Takamatsu, Reika
Nabandith, Viengvansay
Pholsena, Vatsana
Yoshimi, Naoki
Authors affiliation :Department of Pathology and Oncology, Graduate School of Medicine
Setthathirath Hospital, Vientiane, Lao PDR.
Issue Date :2019
Publisher :琉球医学会
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :1346-888X
Abstract :Human papillomavirus (HPV) infection is thought to be a primary cause of cervical cancer, especially the high-risk (HR)-HPV genotype group that causes the development of neoplastic lesions. HPV testing is being conducted worldwide to clarify the risk of cervical cancer. Lao Peopleʼs Democratic Republic (Lao PDR) is one of the developing countries located in Southeast Asia. HPV genotype distribution analysis has not been comprehensively conducted in Lao PDR. In this study, cervical cytology and presence of HR-HPV were examined, using both hybrid capture 2 (HC2) and polymerase chain reaction (PCR) methods, with self-collected cervical samples from 297 healthy asymptomatic women in Oudomxay district, a northern rural district of Lao PDR. The overall rate of abnormal cytology in Oudomxay was 9.8%. HR-HPV positivity rates by HC2 and PCR were 22.9% and 9.1%, respectively. The most prevalent HR-HPV genotype was HPV 58, followed by HPV 16 and 33 in Oudomxay. Considering together with our previous data in Vientiane, the overall HR-HPV positivity rate and frequencies of HPV 16 and 58 increased as cytological morphology deteriorated. The present results suggest that HPV 58 is associated with high-grade cervical lesions, similar to HPV 16, in Lao PDR.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/24768
Citation :琉球医学会誌 = Ryukyu Medical Journal Vol.38 no.1-4 p.25 -34
Appears in Collections:Ryukyu Medical Journal

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