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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/23670

 
Title :慢性腎臓病の病態に基づいた個別化治療の実践と今後の展開
Title alternative :Optimized therapy for chronic kidney disease based on individual pathogenesis and future directions
Authors :古波蔵, 健太郎
Authors alternative :Kohagura, Kentaro
Authors affiliation :琉球大学医学部付属病院血液浄化療法部
Issue Date :Dec-2017
Publisher :琉球医学会
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :1346-888X
Abstract :Chronic kidney disease (CKD) is a major public health issue worldwide. Secondary changes in glomerular hemodynamics accelerate the progression of CKD. Afferent arterioles have a pivotal role in the regulation of glomerular hemodynamics. We conducted some experimental studies to examine the mechanisms underlying the regulation of afferent arteriolar tone using a micro perfusion technique. Furthermore, we tried to evaluate changes in glomerular hemodynamics by observing morphological changes in afferent arterioles and glomeruli using specimen of renal biopsy. We achieved great success in the treatment of CKD by applying such morphological evaluation for the optimization of personal treatment strategies. Furthermore, we published some clinical and experimental papers regarding renal arteriolopathy, which focused on the pathogenesis of cardiorenal connection as well as the progression of CKD. In the near future, we plan to establish a framework for an optimized therapy of CKD based on individual pathogenesis and regional medical network system in Okinawa, Japan.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/23670
Citation :琉球医学会誌 = Ryukyu Medical Journal Vol.36 no.1-2 p.1 -7
Appears in Collections:Ryukyu Medical Journal

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