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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/23669

 
Title :個別化医療の実現を目指して : 2型糖尿病疾患感受性遺伝子の解明とその臨床応用
Title alternative :Elucidation of genetic susceptibility for type 2 diabetes and its clinical application
Authors :今村, 美菜子
Authors alternative :Imamura, Minako
Authors affiliation :琉球大学大学院医学研究科
Issue Date :Dec-2017
Publisher :琉球医学会
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :1346-888X
Abstract :It has been well known that genetic susceptibility contributes to the risk for type 2 diabetes. Genome-wide association studies (GWAS) have facilitated a substantial and rapid rise in the number of confirmed susceptibility variants for type 2 diabetes. To date, more than 90 type 2 diabetes susceptibility loci have been identified through GWAS. Recently our Japanese study group conducted large-scaled GWAS meta-analysis in the Japanese populations and identified seven novel susceptibility loci for type 2 diabetes. Although the impact of the each GWAS-derived susceptibility locus to the disease risk is modest, accumulation of genetic information in individuals is useful to define a high risk group for the disease in a population. Intensive life style intervention for individuals at genetically high risk may lead efficient prevention of type 2 diabetes in the community. Because the current set of established susceptibility loci accounts for only 10% of genetic susceptibility for type 2 diabetes, more effort to search for the missing heritability would be necessary for translation of genetic information into clinical practice. Functional analysis to uncover the molecular mechanisms for type 2 diabetes susceptibility and integrated studies including genetic factor, environmental factor and interaction between genetic and environmental factors are the future challenges.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/23669
Citation :琉球医学会誌 = Ryukyu Medical Journal Vol.36 no.1-2 p.9 -15
Appears in Collections:Ryukyu Medical Journal

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