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このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/20.500.12001/23667

 
タイトル :Evaluation of candidate therapies using a patient-derived cervical cancer xenograft model
著者 :Nagayama-Urasoe, Chiaki
Umikawa, Masato
Asato, Tsuyoshi
Nagai, Yutaka
Aoki, Yoichi
Kariya, Ken-ichi
著者所属 :Department of Medical Biochemistry, Graduate School of Medicine
作成日 :2017-12
公開者・出版者 :琉球医学会
収録種別 :雑誌掲載論文
NIIタイプ :Journal Article
ISSN :1346-888X
内容記述 :Patient-derived xenograft (PDX) models are useful for preclinical evaluation of anticancer agents. However, establishing PDX models of cervical cancers are known to be challenging. We modified a protocol from the existing literature and established a model of an HPV16-positive squamous cell carcinoma on scid mice. The xenograft was positive for p16INK4a even after a passage, indicating the continued involvement of the E7 viral oncoprotein in abnormal cell growth. After 24 days of treatment with a nucleoside analog, gemcitabine, tumor growth was found to be suppressed in a dose-dependent manner, and the tumor became undetectable after high-dose treatment. Cediranib, an orally bioavailable inhibitor of neovascularization, reversed tumor growth until it was barely detectable. A hydrophobic cancer stem cell inhibitor, salinomycin, did not show any significant effect when used alone, but showed a tendency to act synergistically with low-dose gemcitabine. Although further procedural refinements are required, the model appeared to be useful for preclinical evaluation of various anticancer agents, including novel ones that target specific molecules.
権利 :琉球医学会
URI :http://hdl.handle.net/20.500.12001/23667
掲載雑誌 :琉球医学会誌 = Ryukyu Medical Journal Vol.36 no.1-2 p.25 -28
出現コレクション:琉球医学会誌

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