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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/2282

Title :[原著]再発悪性グリオ-マに対するIFN-β局所投与とACNU動注療法の試み
Title alternative :Combined Treatment of Local Injection IFN-β and Intracarotid Injection of ACNU to Recurrent Malignant Gliomas
Authors :仲宗根, 進
六川, 二郎
高良, 英一
銘苅, 晋
石川, 泰成
久田, 均
Authors alternative :Nakasone, Susumu
Mukawa, Jiro
Takara, Eiichi
Mekaru, Susumu
Ishikawa, Yasunari
Kuda, Hitoshi
Authors affiliation :琉球大学医学部脳神経外科
Issue Date :1991
Publisher :琉球大学医学部
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :0289-1530
Abstract :Five cases of recurrent malignant gliomas were treated with local injection of interferon- βcombined with intracarotid injection of 1-(4-amino 2methy1-5-pyrimidinyl)methy1 -3-(2-chlor∝thy1)-3-nitrosourea hydrochloride(ACNU). All patients had been already treated with intravenous injection of IFN-β and/or ACNU as well as conventional radiotherapy after surgery. IFN-β(3×10^6 IU, 3 times a week) was locally injected through a catheter placed into tumor-removed cavity. ACNU (100mg/6weeks) was injected into the carotid artery following osmotic blood brain barrier modification produced by arterial injetion of 20% 200ml mannitol. Multiple intracranial lesions were checked with contrast enhanced CT in all cases. None of the cases exhibited clinical regression. But three of them showed tumor regression around the IFN-β injected cavity, although the other part of the tumor remained progressive. These results suggested that direct tumorddal effects of IFN-β was exhibited to recurrent malignant gliomas, and local injection of IFN-β is so useful that should be used from the initial stage in addition to its intravenous use. There should be some strategic ideas to overcome ACNU resistance when reused.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/2282
Citation :琉球大学医学会雑誌 : 医学部紀要 = Ryukyu medical journal Vol.11 no.3-4 p.131 -140
Appears in Collections:Ryukyu medical journal

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