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このアイテムの引用には次の識別子を使用してください: http://hdl.handle.net/20.500.12001/21686

 
タイトル :[総説]悪性リンパ腫に関するこれまでの研究と琉球大学における今後の研究の方向性について
別言語のタイトル :[Review]My previous research on malignant lymphoma and future theme
著者 :加留部, 謙之輔
別言語の著者 :Karube, Kennosuke
著者所属 :琉球大学大学院医学研究科 細胞病理学講座
Cell Biology & Pathology, Graduate School of Medicine
作成日 :2015-12
公開者・出版者 :琉球医学会
収録種別 :雑誌掲載論文
NIIタイプ :Journal Article
ISSN :1346-888X
内容記述 :This review paper summarizes several studies performed by the author and colleagues so far. The main theme of these studies is malignant lymphoma, one of the most frequent hematological malignancies. Some of these studies were based on clinico-pathological analysis while more basic research techniques including comprehensive genomic analysis and functional analyses were used in the others. Follicular lymphoma (FL), adult T-cell leukemia/lymphoma (ATLL), natural -killer cell lymphoma (NKCL) and diffuse large B-cell lymphoma (DLBCL) are four malignant lymphomas in which the author focused on. Expression of MUM1, one of representative plasma cell markers, were associated with unique clinicopathological characteristics of FL such as lack of t(14;18), most frequent genomic aberration in FL. FOXP3, a master transcriptional factor of regulatory T-cell (Treg), was expressed in about 30% of ATLL cases and its expression was correlated with immunosuppressive state of ATLL patients. With the result of this study, Treg is considered to be a normal counterpart of ATLL tumor cells now. Comprehensive genomic analysis revealed that 6q21 was the most frequently deleted region in NKCL. Functional analysis using gene introduction to cell lines clarified that FOXO3 and PRDM1, a cell cycle regulator and a molecule associated with NK cell differentiation, respectively, are important tumor suppressor genes located on 6q21. Authors are now progressing a comprehensive study on DLBCL, using targeted mutation analysis combined with other molecular techniques. In this study, an automated drug identification method using information of genetic alterations and computer algorithms, named as “in silico prescription” was used to assume how many patients will be benefited by off-label prescription. With these backgrounds and research careers, future plans are proposed in the last part. Construction of a clinico-pathological database and a tissue bank of hematological malignancies is one of the main themes. Periodical fruitful discussions and sharing information between clinicians and pathologists are essential to carry out this theme. Finally, the actualization of comprehensive cancer genome database and daily in silico prescription in the cancer medicine in Okinawa is one of main goals and interests of the author.
権利 :琉球医学会
URI :http://hdl.handle.net/20.500.12001/21686
掲載雑誌 :琉球医学会誌 = Ryukyu Medical Journal Vol.34 no.1・2 p.13 -21
出現コレクション:琉球医学会誌

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