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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/2161

 
Title :[原著]Effects of dipeptides containing L-glutamic acid on the excitability of identifiable giant neurones of the African giant snail (Achatina fulica Ferussac).
Authors :Endo, Iwao
Tamura, Hiroko
Takeuchi, Hiroshi
Takehara, Hiroo
Authors affiliation :2nd Department of Surgery, Ryukyu University Hospital
Department of Neurochemistry, Institute for Neurobiology, Okayama University Medical School
1st Department of Surgery, Tokushima University, Medical School
Issue Date :1980
Publisher :琉球大学保健学部
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :0285-9270
Abstract :In a fine series of pioneering works, Kakimoto, Kanazawa, Nakajima, Sano et al.^<1-6)> reported the presence of many dipeptides, especially those containing L-glutamic acid, in the mammalian central nervous systems. However, the physiological roles of these peptides have not yet been investigated. Takeuchi, Tamura et al^<15-18)> demonstrated using the two identifiable giant neurones (TAN, tonically autoactive neurone and PON, periodically oscillating neurone) of the Afncan giant snail (Achatina fulica Ferussac) that the two aromatic dipeptides, L-Phe-L-Tyr and LPhe-L-Trp, had a marked inhibitory effect on neuronal excitability, and that the tripeptide, $ \gamma $-LGlu-L-Phe-L-Tyr, had a stronger effect than the two aromatic dipeptides mentioned above. Besides, it was also reported by Takeuchi, Yokoi et al.^<20, 22-24)> that some derivatives of L-glutamic acid (L-Glu), for example, erythro-$ \beta $ hydroxy-L-Glu, had a remarkable inhibitory effect, although neither LGlu nor D-Glu had any effect on the same neurone. In the present study, we examined effects of L-Glu-containing dipeptides on the excitability of the two identifiable giant neurones (TAN and PON) of Achatina fulica Ferussac Some of the dipeptides examined have been demonstrated to exist in the central nervous systems.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/2161
Citation :琉球大学保健学医学雑誌=Ryukyu University Journal of Health Sciences and Medicine Vol.3 no.1 p.1 -8
Appears in Collections:Ryukyu University Journal of Health Sciences and Medicine

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