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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/2125

Title :[原著]Streptozotocin Therapy for A Total Gastrectomized Malignant Gastrinoma
Authors :Endo, Iwao
Omata, Shozo
Sajima, Keisei
Ito, Etsuo
Authors affiliation :Second Department of Surgery, Ryukyu University Hospital, College of Health Sciences, University of the Ryukyus, Naha city, Japan
Yokohama Shimin City Hospital, Yokohama city, Japan
Department of Pathology, College of Health Sciences, University of the Ryukyus, Naha city, Japan
Issue Date :1981
Publisher :琉球大学保健学部
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :0285-9270
Abstract :A case of malignant gastrinoma where streptozotocin was effective is reported; the course after total gastrectomy of this malignancy are discussed. Malignant gastrinoma may continue to progress even after total gastrectomy to terminate fatally. Angiogram, assessment of serum gastrin levels loaded with secretin, scintigram are useful indices for observation of the course. Streptozotocin has a good effect on malignant gastrinoma, while mitomycin C, 5-fluorouracil, combined chemotherapy with 5-fluorouracil, 250mg, cyclophosphamide, 150mg, mitomycin C, 2mg and chromomycin A_3, 0.5mg, at a time twice weekly (FAMT therapy) have all proved ineffective. It used to be considered that total gastrectomy would lead malignant gastrinoma to regression of its metastases and the case would run a favorable course because of its low malignancy. ^<1.2.3> Therefore, it was not commonly accepted that the patient with this tumor would die of their tumor after total gastrectomy. However, as long-term experience with this tumor has accumulated, those terminating fatally of the tumor even after total gastrectomy have been encountered, making it necessary to perform some adjuvant therapy in them.^4 We report a case of malignant gastrinoma treated by total gastrectomy which followed by administration of streptozotocin and discuss the course, treatment and indices of observation of the course of this tumor after total gastrectomy.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/2125
Citation :琉球大学保健学医学雑誌=Ryukyu University Journal of Health Sciences and Medicine Vol.3 no.4 p.339 -350
Appears in Collections:Ryukyu University Journal of Health Sciences and Medicine

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