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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/2084

 
Title :[原著]ミャンマー人における口唇口蓋裂発症とMTHFR遺伝子C677T多型の関連に対する検討
Title alternative :Association of MTHFR Gene Polymorphisms on Nonsyndromic Isolated Cleft Lip and with or without cleft palate in a Myanmar population.
Authors :後藤, 尊広
新垣, 敬一
國仲, 梨香
石川, 拓
仲間, 錠嗣
夏目, 長門
大関, 悟
砂川, 元
Authors alternative :Goto, Takahiro
Arakaki, Keiichi
Kuninaka, Rika
Ishikawa, Taku
Nakama, Joji
Natsume, Nagato
Ozeki, Satoru
Sunakawa, Hajime
Authors affiliation :琉球大学医学部高次機能医科学講座顎顔面口腔機能再建学分野
愛知学院大学歯学部口腔先天異常学研究室
福岡歯科大学口腔顎顔面外科学講座口腔腫瘍学分野
Issue Date :2009
Publisher :琉球医学会
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :1346-888X
0289-1530
Abstract :Objective: The aim of this study was to evaluate the association between folate metabolizing enzyme gene polymorphism, 5,10-methylenetetrahydrofolate reductase (MTHFR) gene polymorphism C677T and the development of isolated non-syndromic cleft lip with or without cleft palate (NSCL/P) in a Myanmar population. Patients/- Participants: We examined 156 Myanmar isolated NSCL/P patients, 96 their mothers and 64 their fathers compared to 109 controls. Results: The genotype and allele frequencies of MTHFR C677T in Myanmar isolated NSCL/P did not show statistically differences between the patient and the control group (p=0.813, 0.535) as well as the father (p=0.513, 0.267), the mother (p=0.501, 0.420) and the control group (Genotype frequency, Allele frequency). Conclusion: Our results did not suggest that MTHFR C677T polymorphism does not make a important role in the development of isolated NSCL/P in a Myanmar population.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/2084
Citation :琉球医学会誌 = Ryukyu Medical Journal Vol.28 no.1・2 p.25 -29
Appears in Collections:Ryukyu Medical Journal

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