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Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12001/1942

Title :[原著]A Prospective Trial of Oral Betamethason and Oral Lorazepam in the Management of Delayed Nausea and Vomiting Induced by Cisplatin-Based Chemotherapy
Authors :Uehara, Tadashi
Yohena, Tomofumi
Kanematsu, Takanori
Teruya, Takao
Ikeda, Jiro
Okamoto, Junichi
Asoh, Hiroshi
Ichinose, Yukito
Authors affiliation :Department of Thoracic Oncology, National Kyushu Cancer Center, Fukuoka, Japan
Department of Surgery, Naha City Hospital, Okinawa, Japan
Issue Date :2006
Publisher :琉球医学会
Type Local :雑誌掲載論文
Type (NII) :Journal Article
ISSN :1346-888X
Abstract :Purpose: The optimal treatment modality for delayed emesis occurring later than 24 hours after the administration of cisplatin-based chemotherapy has not yet been established. Patients and Methods: Twenty patients received 5-hydroxytryptamine 3 receptor antagonist intravenously for the treatment of acute emesis just before cisplatm infusion in the first cycle of treatment, and the thereafter they received oral administration of betamethason ($\2mgtimes3/day$) plus oral lorazepam ($\0.5mgtimes3/day$) for 5 days in trial I. In trial II, 14 patients who received the other anti-emetic regimen (methylprednisolone plus metoclopramide) for delayed emesis in the first cycle of chemotherapy were treated by this regimen for the second cycle of treatment. A complete response (CR) was defined as no emetic episodes and a partial response (PR) as no vomiting episodes but some nausea. The effects of anti-emetic treatments were evaluated for 5 days from the next day after cisplatin administration. Results: The mean control rate (percentage of CR+PR) and CR rate for delayed emesis for the 5-day period were 97% and 84%, respectively in trial I. The mean control rate in patients undergoing the other anti-emetic regimen in the first cycle of chemotherapy was 60% compared to 96% in the same patients undergoing this regimen in the second cycle of the same chemotherapy in trial II. Conclusions: Oral betamethason plus lorazepam demonstrated a high control rate for delayed nausea and vomiting induced by cisplatin-based chemotherapy.
Rights :琉球医学会
URI :http://hdl.handle.net/20.500.12001/1942
Citation :琉球医学会誌 = Ryukyu Medical Journal Vol.25 no.1・2 p.17 -22
Appears in Collections:Ryukyu Medical Journal

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